The most celebrated study that claims to show brain damage is the rhesus monkey study of Dr. Robert Heath, done in the late 1970s. This study was reviewed by a distinguished panel of scientists sponsored by the Institute of Medicine and the National Academy of Sciences. Their results were published under the title, Marijuana and Health in 1982. Heath's work was sharply criticized for its insufficient sample size (only four monkeys), its failure to control experimental bias, and the misidentification of normal monkey brain structure as "damaged". Actual studies of human populations of marijuana users have shown no evidence of brain damage. For example, two studies from 1977, published in the Journal of the American Medical Association (JAMA) showed no evidence of brain damage in heavy users of marijuana. That same year, the American Medical Association (AMA) officially came out in favor of decriminalizing marijuana. That's not the sort of thing you'd expect if the AMA thought marijuana damaged the brain.